منابع مشابه
Cellular oncogenes in neoplasia.
In recent years cellular homologues of many viral oncogenes have been identified. As these genes are partially homologous to viral oncogenes and are activated in some tumour cell lines they are termed "proto-oncogenes". In tumour cell lines proto-oncogenes are activated by either quantitative or qualitative changes in gene structure: activation of these genes was originally thought to be a nece...
متن کاملViral oncogenes and cellular prototypes.
The structural hallmark of retroviral transforming onc genes is a specific RNA sequence that is unrelated to the essential retroviral genes but closely related to certain cellular prototypes termed proto-onc genes. Two types of onc genes have been distinguished. Type I are onc genes which utilize elements of specific sequences only to encode a transforming protein. Type I1 onc genes are hybrids...
متن کاملRetroviral and human cellular oncogenes.
Unexpected meeting of two separate lines of research resulted in the discovery of oncogenes. Oncogenes are deoxyribonucleic acid (DNA) sequences coding for polypeptide gene products which cause, or contribute to, neoplastic growth of cells. Oncogenes remain almost unchanged through evolution: oncogenes and their gene products of avian, murine, feline, simian and human species show close homolog...
متن کاملActivation of p53 by oncogenes.
p53 is activated by a variety of cellular stresses, including DNA damage, hypoxia, and mitogenic oncogenes, but the extent to which each signal engages p53 as a tumour suppressor remains unknown. In non-immortal cells, the adenovirus E1A oncogene activates p53 to promote apoptosis, whereas oncogenic ras activates p53 to promote cellular senescence. Inactivation of p53 prevents E1A-induced apopt...
متن کاملThe molecular genetics of cellular oncogenes.
DEFINITIONS OF CELLULAR ONCOGENES ................................................ c-onc’s: The Proto-Oncogenic Progenitors of Retroviral Oncogenes . . . . . . . . . . . . . . . . . . . Identification of Cellular Oncogenes by Functional Tests for Dominant Mutations Using Genetic Rearrangements to Identify Oncogenes.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Proviral...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1986
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.35.32